Head-to-head
TMates vs Enhance MD
Compared on both medications across the eight dimensions this database records. They differ on 3 of those eight. Enhance MD is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
TMates is $297 a month all-in for tirzepatide; Enhance MD is $280. Over twelve months that is $2,004 against $3,360. Value Scores are 55.3 and 57.8 out of 100.
Tirzepatide
Plan pages: TMates plans · Enhance MD plans
At 10 mg/week, TMates is $297 a month all-in and Enhance MD is $280 — $17 apart, or $204 across a year. Over twelve months the totals are $2,004 (prepaid term) and $3,360 (billed monthly).
TMates charges a flat $297 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
Enhance MD prices tirzepatide by dose: $169 per month at 2.5 mg rising to $280 at 10 mg, a difference of $111 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | TMates | Rank | Enhance MD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $297 | 16/31 | $169 | 2/31 | Enhance MD by $128 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $297 | 12/27 | $280 | 9/27 | Enhance MD by $17 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, TMates sits 10 of 27 on all-in monthly cost and Enhance MD sits 7. There are 2 other programs priced between them. The field median is $339 and the floor is $169, so both sit below the median. TMates is $128 above the cheapest tirzepatide program on record. Enhance MD is $111 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — TMates undercuts it by $152, Enhance MD by $169. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | TMates | Enhance MD | Cheaper |
|---|---|---|---|
| Month to month | $297 | $280 | Enhance MD by $17 |
| 12-month term | $167 | — | only TMates publishes this term |
| Settled dose | TMates | Enhance MD | Difference |
|---|---|---|---|
| 2.5 mg | $3,564 | $2,028 | $1,536 apart |
| 10 mg | $3,564 | $3,360 | $204 apart |
TMates publishes no rate for 3-month term, 6-month term; Enhance MD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,564 on TMates and $3,249 on Enhance MD — $315 apart, and a different gap from the $204 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: TMates publishes no price at 2 of the 6 doses and Enhance MD publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 55.3 for TMates and 57.8 for Enhance MD, against a tirzepatide category floor of $169. Enhance MD leads by 2.5 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| TMates | 39.8 | 10.5 | 0 | 5 | 55.3 |
| Enhance MD | 42.2 | 10.5 | 0 | 5 | 57.8 |
Semaglutide
Plan pages: TMates plans · Enhance MD plans
At 2.4 mg/week, TMates is $249 a month all-in and Enhance MD is $212 — $37 apart, or $444 across a year. Over twelve months the totals are $1,896 (prepaid term) and $2,544 (billed monthly).
TMates charges a flat $249 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Enhance MD charges a flat $212 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 51.8 for TMates and 58.1 for Enhance MD, against a semaglutide category floor of $129. Enhance MD leads by 6.3 points, driven mostly by price.
Where the two programs differ
All-in monthly
Enhance MD is cheaper month to month — $280 against $297, a gap of $17 every month, or $204 across a year if both rates hold.
Commitment
TMates asks for 12-month plan or month-to-month; substantial difference in rates; Enhance MD asks for Monthly, with a first-month discount on GLP-1 Core ($112 first month). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Twelve-month cost
Over twelve months the totals are $2,004 for TMates and $3,360 for Enhance MD. TMates is lower by $1,356 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Cancellation terms
Both state the same cancellation terms: Per provider terms.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Evidence status
Both figures carry the same evidence status, reported: sourced from dated third-party reporting; first-party capture pending. Neither is stronger than the other on provenance.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
TMates Official site
TMates is a compounded GLP-1 telehealth service that includes medication and visits in one bundled monthly price. It offers both semaglutide and tirzepatide, with a 12-month plan that brings tirzepatide to $167/mo — the lowest committed-plan figure for tirz outside of bmiMD and NexLife.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are 12-month plan or month-to-month; substantial difference in rates; cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, capture 2026-07-14
Watch: The $158/mo (sema) and $167/mo (tirz) headline figures are 12-month plan rates; month-to-month is $249 (sema) and $297 (tirz) — some of the widest start-to-commitment spreads in the index. Reported status from RangeYourself 2026-07-14 verification.
Enhance MD Official site
Enhance MD bundles GLP-1 medication inside a broader metabolic program including NAD+ coaching, lab testing every six months, and ongoing provider care. The price reflects the full metabolic bundle, not the GLP-1 alone; this makes Enhance MD's figures the least comparable in the database.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly, with a first-month discount on GLP-1 Core ($112 first month); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Enhance MD verified 2026-07-14; price reflects metabolic bundle, not GLP-1 alone
Watch: Figures reflect the bundled metabolic program price, not GLP-1 medication alone. Comparing Enhance MD's $212–$322 to medication-only programs overstates the GLP-1 cost while understating the breadth of service included. The $169 microdosing figure is the most medication-proximate but involves a different dosing protocol. Reported — RangeYourself 2026-07-14.
What neither record tells you
TMates does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Enhance MD does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask TMates and Enhance MD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. TMates, Enhance MD carry a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Prepaid terms move the annual figures. TMates publishes a twelve-month rate of $167 a month against $297 month-to-month. Read those next to the cancellation terms, not the monthly rate.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Enhance MD Official site wins this matchup. On the structural dimensions the two are close enough that the choice comes down to availability in your state and which intake you prefer.
Both figures should be checked at the provider's own checkout before you pay. TMates's tirzepatide price is reported as of 2026-07-14; Enhance MD's is reported as of 2026-07-14.
Questions
Is TMates or Enhance MD cheaper for tirzepatide?
Enhance MD is cheaper on all-in monthly cost at 10 mg/week: $280 against $297, a difference of $17 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of TMates versus Enhance MD?
TMates works out to $2,004 across twelve months and Enhance MD to $3,360, on the plan terms each publishes.
Does TMates or Enhance MD raise the price as the dose goes up?
TMates: yes, it prices by dose. Enhance MD: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do TMates and Enhance MD differ?
3 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of TMates and Enhance MD names its pharmacy?
Neither. TMates records Partner 503A pharmacy (not publicly named) and Enhance MD records Partner 503A pharmacy (not named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the TMates and Enhance MD prices?
TMates's tirzepatide figure is reported — sourced from dated third-party reporting; first-party capture pending — captured 2026-07-14. Enhance MD's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Enhance MD, at $212 a month all-in against $249 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: TMates official site · Enhance MD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.