Head-to-head
ShedRx vs TMates
Compared on both medications across the eight dimensions this database records. They differ on 5 of those eight. ShedRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
ShedRx is $289 a month all-in for tirzepatide; TMates is $297. Over twelve months that is $3,468 against $2,004. Value Scores are 58.7 and 55.3 out of 100.
Tirzepatide
Plan pages: ShedRx plans · TMates plans
At 10 mg/week, ShedRx is $289 a month all-in and TMates is $297 — $8 apart, or $96 across a year. Over twelve months the totals are $3,468 (billed monthly) and $2,004 (prepaid term).
ShedRx prices tirzepatide by dose: $199 per month at 2.5 mg rising to $289 at 10 mg, a difference of $90 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
TMates charges a flat $297 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | ShedRx | Rank | TMates | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $199 | 7/31 | $297 | 16/31 | ShedRx by $98 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $289 | 11/27 | $297 | 12/27 | ShedRx by $8 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, ShedRx sits 8 of 27 on all-in monthly cost and TMates sits 10. There is 1 other program priced between them. The field median is $339 and the floor is $169, so both sit below the median. ShedRx is $120 above the cheapest tirzepatide program on record. TMates is $128 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — ShedRx undercuts it by $160, TMates by $152. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | ShedRx | TMates | Cheaper |
|---|---|---|---|
| Month to month | $289 | $297 | ShedRx by $8 |
| 12-month term | — | $167 | only TMates publishes this term |
| Settled dose | ShedRx | TMates | Difference |
|---|---|---|---|
| 2.5 mg | $2,388 | $3,564 | $1,176 apart |
| 10 mg | $3,468 | $3,564 | $96 apart |
ShedRx publishes no rate for 3-month term, 6-month term, 12-month term; TMates publishes none for 3-month term, 6-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,378 on ShedRx and $3,564 on TMates — $186 apart, and a different gap from the $96 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: ShedRx publishes no price at 2 of the 6 doses and TMates publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 58.7 for ShedRx and 55.3 for TMates, against a tirzepatide category floor of $169. ShedRx leads by 3.4 points, and the margin comes from structure rather than price alone.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| ShedRx | 40.9 | 12.8 | 0 | 5 | 58.7 |
| TMates | 39.8 | 10.5 | 0 | 5 | 55.3 |
Semaglutide
Plan pages: ShedRx plans · TMates plans
At 2.4 mg/week, ShedRx is $249 a month all-in and TMates is $249, identical figures. Over twelve months the totals are $2,988 (billed monthly) and $1,896 (prepaid term).
ShedRx prices semaglutide by dose: $175 per month at 0.25 mg rising to $249 at 2.4 mg, a difference of $74 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
TMates charges a flat $249 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 54.0 for ShedRx and 51.8 for TMates, against a semaglutide category floor of $129. ShedRx leads by 2.2 points, and the margin comes from structure rather than price alone.
Where the two programs differ
All-in monthly
ShedRx is cheaper month to month — $289 against $297, a gap of $8 every month, or $96 across a year if both rates hold.
Cancellation terms
Cancellation differs: ShedRx states Cancel before renewal, while TMates states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
ShedRx asks for Month-to-month; TMates asks for 12-month plan or month-to-month; substantial difference in rates. This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. ShedRx's figure is provider-stated and TMates's is reported. ShedRx rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $3,468 for ShedRx and $2,004 for TMates. TMates is lower by $1,464 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
ShedRx Official site
ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — shedrx.com pricing capture 2026-08-05
Watch: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
TMates Official site
TMates is a compounded GLP-1 telehealth service that includes medication and visits in one bundled monthly price. It offers both semaglutide and tirzepatide, with a 12-month plan that brings tirzepatide to $167/mo — the lowest committed-plan figure for tirz outside of bmiMD and NexLife.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are 12-month plan or month-to-month; substantial difference in rates; cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, capture 2026-07-14
Watch: The $158/mo (sema) and $167/mo (tirz) headline figures are 12-month plan rates; month-to-month is $249 (sema) and $297 (tirz) — some of the widest start-to-commitment spreads in the index. Reported status from RangeYourself 2026-07-14 verification.
What neither record tells you
ShedRx does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
TMates does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask ShedRx and TMates for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. TMates carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Prepaid terms move the annual figures. TMates publishes a twelve-month rate of $167 a month against $297 month-to-month. Read those next to the cancellation terms, not the monthly rate.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, ShedRx Official site wins this matchup. And if you would rather trust a better-evidenced number, shedrx's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. ShedRx's tirzepatide price is provider-stated as of 2026-08-05; TMates's is reported as of 2026-07-14.
Questions
Is ShedRx or TMates cheaper for tirzepatide?
ShedRx is cheaper on all-in monthly cost at 10 mg/week: $289 against $297, a difference of $8 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of ShedRx versus TMates?
ShedRx works out to $3,468 across twelve months and TMates to $2,004, on the plan terms each publishes.
Does ShedRx or TMates raise the price as the dose goes up?
ShedRx: yes, it prices by dose. TMates: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do ShedRx and TMates differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of ShedRx and TMates names its pharmacy?
Neither. ShedRx records Partner pharmacies and TMates records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the ShedRx and TMates prices?
ShedRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. TMates's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
ShedRx, at $249 a month all-in against $249 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: ShedRx official site · TMates official site. Compounded tirzepatide and semaglutide are not FDA-approved products.