Head-to-head
ShedRx vs LillyDirect (Zepbound)
Compared on tirzepatide across the eight dimensions this database records. They differ on 5 of those eight. ShedRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
ShedRx is $289 a month all-in for tirzepatide; LillyDirect (Zepbound) is $449. Over twelve months that is $3,468 against $5,388. Value Scores are 48.3 and 39.6 out of 100.
Tirzepatide
Plan pages: ShedRx plans · LillyDirect (Zepbound) plans
At 10 mg/week, ShedRx is $289 a month all-in and LillyDirect (Zepbound) is $449 — $160 apart, or $1,920 across a year. Over twelve months the totals are $3,468 (billed monthly) and $5,388 (billed monthly).
ShedRx prices tirzepatide by dose: $199 per month at 2.5 mg rising to $289 at 10 mg, a difference of $90 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
LillyDirect (Zepbound) prices tirzepatide by dose: $299 per month at 2.5 mg rising to $449 at 7.5 mg, a difference of $150 a month between the bottom and top of the ladder.
| Dose | ShedRx | LillyDirect (Zepbound) | Cheaper |
|---|---|---|---|
| 2.5 mg | $199 | $299 | ShedRx by $100 |
| 5 mg | — | $399 | only LillyDirect (Zepbound) publishes |
| 7.5 mg | — | $449 | only LillyDirect (Zepbound) publishes |
| 10 mg | $289 | $449 | ShedRx by $160 |
| 12.5 mg | — | $449 | only LillyDirect (Zepbound) publishes |
| 15 mg | — | $449 | only LillyDirect (Zepbound) publishes |
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, the field median is $299 a month all-in. ShedRx, at $289, is $10 below it; LillyDirect (Zepbound), at $449, is $150 above it.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide price in this database, is $449 a month at 10 mg/week — ShedRx is $160 below it. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | ShedRx | LillyDirect (Zepbound) | Cheaper |
|---|---|---|---|
| Month to month | $289 | $449 | ShedRx by $160 |
| Settled dose | ShedRx | LillyDirect (Zepbound) | Difference |
|---|---|---|---|
| 2.5 mg | $2,388 | $3,588 | $1,200 apart |
| 5 mg | — | $4,788 | one side unpriced |
| 7.5 mg | — | $5,388 | one side unpriced |
| 10 mg | $3,468 | $5,388 | $1,920 apart |
| 12.5 mg | — | $5,388 | one side unpriced |
| 15 mg | — | $5,388 | one side unpriced |
ShedRx publishes no rate for 3-month term, 6-month term, 12-month term; LillyDirect (Zepbound) publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,378 on ShedRx and $5,188 on LillyDirect (Zepbound) — $1,810 apart, and a different gap from the $1,920 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: ShedRx publishes no price at 2 of the 6 doses, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 48.3 for ShedRx and 39.6 for LillyDirect (Zepbound), against a tirzepatide category floor of $126. ShedRx leads by 8.7 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| ShedRx | 30.5 | 12.8 | 0 | 5 | 48.3 |
| LillyDirect (Zepbound) | 19.6 | 15.0 | 0 | 5 | 39.6 |
Where the two programs differ
All-in monthly
ShedRx is cheaper month to month — $289 against $449, a gap of $160 every month, or $1,920 across a year if both rates hold.
Cancellation terms
Cancellation differs: ShedRx states Cancel before renewal, while LillyDirect (Zepbound) states No subscription lock. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
ShedRx asks for Month-to-month; LillyDirect (Zepbound) asks for None; Journey Program pricing requires refill within 45 days on 7.5 mg+. This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. ShedRx's figure is provider-stated and LillyDirect (Zepbound)'s is verified. LillyDirect (Zepbound) rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $3,468 for ShedRx and $5,388 for LillyDirect (Zepbound). ShedRx is lower by $1,920 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
ShedRx Official site
ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — shedrx.com pricing capture 2026-08-05
Watch: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
LillyDirect (Zepbound) Official site
The manufacturer's own cash channel for FDA-approved Zepbound (KwikPen or vial): $299/month at 2.5 mg, $399 at 5 mg, and $449 for every dose from 7.5 to 15 mg through the self-pay program, provided each refill lands within 45 days of the last; otherwise a refill costs $499 at 7.5 mg and $699 at 10 to 15 mg. The savings card allows up to 11 fills a calendar year and its savings end December 31, 2026. It is the lowest FDA-approved tirzepatide price in this database and the benchmark every compounded price should be judged against.
It names its compounding pharmacy — Eli Lilly self-pay pharmacy (GiftHealth), recorded as Manufacturer direct — which can be checked against state board licensing and FDA inspection records before you order; commitment terms are None; Journey Program pricing requires refill within 45 days on 7.5 mg+; cancellation is No subscription lock; availability is stated as 50 states.
Evidence: verified — captured at checkout by our desk on the stated date, captured . Source — Lilly investor announcement Dec 1, 2025 + LillyDirect program pages; corroborated by drugs.com pricing review updated Jun 12, 2026
Watch: The 45-day refill window is the whole game: one late refill at 10 mg costs $699 instead of $449. The current self-pay terms end December 31, 2026.
Which molecules each one carries
ShedRx carries tirzepatide at $289 a month and semaglutide at $249 a month.
LillyDirect (Zepbound) carries tirzepatide at $449 a month; does not offer semaglutide.
Comparable only on tirzepatide: they do not both publish a rankable semaglutide price. Switching molecule mid-treatment would mean changing provider.
What neither record tells you
ShedRx does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
LillyDirect (Zepbound) does not publish
- no published twelve-month tirzepatide rate
Ask ShedRx and LillyDirect (Zepbound) for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Neither program publishes a promotional rate with an end date, a prepaid term, or a price we have flagged for re-verification, so the comparison above is as stable as this dataset gets.
Which one suits which reader
On the lower standing monthly rate for tirzepatide, ShedRx Official site wins this matchup. And if you would rather trust a better-evidenced number, lillydirect (zepbound)'s price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. ShedRx's tirzepatide price is provider-stated as of 2026-08-05; LillyDirect (Zepbound)'s is verified as of 2026-08-11.
Questions
Is ShedRx or LillyDirect (Zepbound) cheaper for tirzepatide?
ShedRx is cheaper on all-in monthly cost at 10 mg/week: $289 against $449, a difference of $160 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of ShedRx versus LillyDirect (Zepbound)?
ShedRx works out to $3,468 across twelve months and LillyDirect (Zepbound) to $5,388, on the plan terms each publishes.
Does ShedRx or LillyDirect (Zepbound) raise the price as the dose goes up?
ShedRx: yes, it prices by dose. LillyDirect (Zepbound): yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do ShedRx and LillyDirect (Zepbound) differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of ShedRx and LillyDirect (Zepbound) names its pharmacy?
LillyDirect (Zepbound) does — Eli Lilly self-pay pharmacy (GiftHealth). ShedRx does not, recording only Partner pharmacies, so who makes its medication cannot be independently verified.
How well evidenced are the ShedRx and LillyDirect (Zepbound) prices?
ShedRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. LillyDirect (Zepbound)'s is verified, captured 2026-08-11. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Official sources: ShedRx official site · LillyDirect (Zepbound) official site. Compounded tirzepatide and semaglutide are not FDA-approved products.