Head-to-head
ShedRx vs LifeMD
Compared on both medications across the eight dimensions this database records. They differ on 5 of those eight. ShedRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
ShedRx is $289 a month all-in for tirzepatide; LifeMD is $597. Over twelve months that is $3,468 against $7,164. Value Scores are 48.3 and 37.5 out of 100.
Tirzepatide
Plan pages: ShedRx plans · LifeMD plans
At 10 mg/week, ShedRx is $289 a month all-in and LifeMD is $597 — $308 apart, or $3,696 across a year. Over twelve months the totals are $3,468 (billed monthly) and $7,164 (billed monthly).
ShedRx prices tirzepatide by dose: $199 per month at 2.5 mg rising to $289 at 10 mg, a difference of $90 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
LifeMD charges a flat $597 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
| Dose | ShedRx | LifeMD | Cheaper |
|---|---|---|---|
| 2.5 mg | $199 | $597 | ShedRx by $398 |
| 5 mg | — | $597 | only LifeMD publishes |
| 7.5 mg | — | $597 | only LifeMD publishes |
| 10 mg | $289 | $597 | ShedRx by $308 |
| 12.5 mg | — | $597 | only LifeMD publishes |
| 15 mg | — | $597 | only LifeMD publishes |
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, the field median is $299 a month all-in. ShedRx, at $289, is $10 below it; LifeMD, at $597, is $298 above it.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide price in this database, is $449 a month at 10 mg/week — ShedRx is $160 below it and LifeMD is $148 above it. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | ShedRx | LifeMD | Cheaper |
|---|---|---|---|
| Month to month | $289 | $597 | ShedRx by $308 |
| Settled dose | ShedRx | LifeMD | Difference |
|---|---|---|---|
| 2.5 mg | $2,388 | $7,164 | $4,776 apart |
| 5 mg | — | $7,164 | one side unpriced |
| 7.5 mg | — | $7,164 | one side unpriced |
| 10 mg | $3,468 | $7,164 | $3,696 apart |
| 12.5 mg | — | $7,164 | one side unpriced |
| 15 mg | — | $7,164 | one side unpriced |
ShedRx publishes no rate for 3-month term, 6-month term, 12-month term; LifeMD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,378 on ShedRx and $7,164 on LifeMD — $3,786 apart, and a different gap from the $3,696 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: ShedRx publishes no price at 2 of the 6 doses, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 48.3 for ShedRx and 37.5 for LifeMD, against a tirzepatide category floor of $126. ShedRx leads by 10.8 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| ShedRx | 30.5 | 12.8 | 0 | 5 | 48.3 |
| LifeMD | 14.8 | 12.8 | 10 | 0 | 37.5 |
Semaglutide
Plan pages: ShedRx plans · LifeMD plans
At 2.4 mg/week, ShedRx is $249 a month all-in and LifeMD is $348 — $99 apart, or $1,188 across a year. Over twelve months the totals are $2,988 (billed monthly) and $4,176 (billed monthly).
ShedRx prices semaglutide by dose: $175 per month at 0.25 mg rising to $249 at 2.4 mg, a difference of $74 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
LifeMD charges a flat $348 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 42.2 for ShedRx and 40.2 for LifeMD, against a semaglutide category floor of $87. ShedRx leads by 2.0 points, driven mostly by price.
Where the two programs differ
All-in monthly
ShedRx is cheaper month to month — $289 against $597, a gap of $308 every month, or $3,696 across a year if both rates hold.
Cancellation terms
Cancellation differs: ShedRx states Cancel before renewal, while LifeMD states Cancel anytime. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Dose policy
LifeMD charges one price at every dose; ShedRx prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Membership fee
LifeMD charges a membership of $149 a month on top of the medication. That is already folded into the all-in figures above — it is broken out here because a membership is a recurring charge that continues even in a month you skip a shipment.
Twelve-month cost
Over twelve months the totals are $3,468 for ShedRx and $7,164 for LifeMD. ShedRx is lower by $3,696 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Commitment
Commitment terms read the same on both: Month-to-month.
Evidence status
Both figures carry the same evidence status, provider-stated: taken from the provider's own published pages; checkout capture pending. Neither is stronger than the other on provenance.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
ShedRx Official site
ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — shedrx.com pricing capture 2026-08-05
Watch: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
LifeMD Official site
LifeMD attaches a $149/month program fee to medication pricing; its compounded tirzepatide all-in figure ($597) is the highest in our index, though its insurance-navigation pathway for brand products is a genuine strength.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel anytime; availability is stated as 50 states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — lifemd.com pricing capture 2026-08-05
Watch: Highest all-in compounded tirzepatide in the index; the value case rests on clinical service and insurance help, not price.
What neither record tells you
ShedRx does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
LifeMD does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
Ask ShedRx and LifeMD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Neither program publishes a promotional rate with an end date, a prepaid term, or a price we have flagged for re-verification, so the comparison above is as stable as this dataset gets.
Which one suits which reader
On the lower standing monthly rate for tirzepatide, ShedRx Official site wins this matchup. If you expect to titrate to the top of the ladder, lifemd's flat pricing is worth more than the headline gap suggests; if you want to be able to pause without still paying, shedrx carries no membership.
Both figures should be checked at the provider's own checkout before you pay. ShedRx's tirzepatide price is provider-stated as of 2026-08-05; LifeMD's is provider-stated as of 2026-08-05.
Questions
Is ShedRx or LifeMD cheaper for tirzepatide?
ShedRx is cheaper on all-in monthly cost at 10 mg/week: $289 against $597, a difference of $308 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of ShedRx versus LifeMD?
ShedRx works out to $3,468 across twelve months and LifeMD to $7,164, on the plan terms each publishes.
Does ShedRx or LifeMD raise the price as the dose goes up?
ShedRx: yes, it prices by dose. LifeMD: no, it charges one flat rate at every dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do ShedRx and LifeMD differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of ShedRx and LifeMD names its pharmacy?
Neither. ShedRx records Partner pharmacies and LifeMD records Partner pharmacies. Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the ShedRx and LifeMD prices?
ShedRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. LifeMD's is provider-stated, captured 2026-08-05. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
ShedRx, at $249 a month all-in against $348 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: ShedRx official site · LifeMD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.