Head-to-head
HealthRX vs Direct Meds
Compared on both medications across the eight dimensions this database records. They differ on 5 of those eight. HealthRX is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
HealthRX is $209 a month all-in for tirzepatide; Direct Meds is $399. Over twelve months that is $2,148 against $4,788. Value Scores are 82.1 and 45.1 out of 100.
Tirzepatide
Plan pages: HealthRX plans · Direct Meds plans
At 10 mg/week, HealthRX is $209 a month all-in and Direct Meds is $399 — $190 apart, or $2,280 across a year. Over twelve months the totals are $2,148 (prepaid term) and $4,788 (billed monthly).
HealthRX charges a flat $209 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | HealthRX | Rank | Direct Meds | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $209 | 11/31 | $299 | 17/31 | HealthRX by $90 |
| 5 mg | $209 | 5/17 | — | — | only HealthRX publishes |
| 7.5 mg | $209 | 5/17 | — | — | only HealthRX publishes |
| 10 mg | $209 | 5/27 | $399 | 20/27 | HealthRX by $190 |
| 12.5 mg | $209 | 5/17 | — | — | only HealthRX publishes |
| 15 mg | $209 | 5/17 | — | — | only HealthRX publishes |
HealthRX is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, HealthRX sits 5 of 27 on all-in monthly cost and Direct Meds sits 22. There are 16 other programs priced between them. The field median is $339 and the floor is $169, so HealthRX is below the median and the other is above it. HealthRX is $40 above the cheapest tirzepatide program on record. Direct Meds is $230 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — HealthRX undercuts it by $240, Direct Meds by $50. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | HealthRX | Direct Meds | Cheaper |
|---|---|---|---|
| Month to month | — | $399 | only Direct Meds publishes this term |
| 3-month term | $209 | — | only HealthRX publishes this term |
| 12-month term | $179 | — | only HealthRX publishes this term |
| Settled dose | HealthRX | Direct Meds | Difference |
|---|---|---|---|
| 2.5 mg | $2,508 | $3,588 | $1,080 apart |
| 5 mg | $2,508 | — | one side unpriced |
| 7.5 mg | $2,508 | — | one side unpriced |
| 10 mg | $2,508 | $4,788 | $2,280 apart |
| 12.5 mg | $2,508 | — | one side unpriced |
| 15 mg | $2,508 | — | one side unpriced |
HealthRX publishes no rate for month to month, 6-month term; Direct Meds publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $2,508 on HealthRX and $4,688 on Direct Meds — $2,180 apart, and a different gap from the $2,280 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Direct Meds publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 82.1 for HealthRX and 45.1 for Direct Meds, against a tirzepatide category floor of $169. HealthRX leads by 37.0 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| HealthRX | 56.6 | 10.5 | 10 | 5 | 82.1 |
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
Semaglutide
Plan pages: HealthRX plans · Direct Meds plans
At 2.4 mg/week, HealthRX is $133 a month all-in and Direct Meds is $297 — $164 apart, or $1,968 across a year. Over twelve months the totals are $1,188 (prepaid term) and $3,564 (billed monthly).
HealthRX charges a flat $133 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
HealthRX is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 93.4 for HealthRX and 45.9 for Direct Meds, against a semaglutide category floor of $129. HealthRX leads by 47.5 points, driven mostly by price.
Where the two programs differ
All-in monthly
HealthRX is cheaper month to month — $209 against $399, a gap of $190 every month, or $2,280 across a year if both rates hold.
Cancellation terms
Cancellation differs: HealthRX states Per provider terms; confirm at enrollment, while Direct Meds states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
HealthRX asks for 12-month or 3-month plans only; no month-to-month rate published; Direct Meds asks for Monthly (no commitment indicated). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Dose policy
HealthRX charges one price at every dose; Direct Meds prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Twelve-month cost
Over twelve months the totals are $2,148 for HealthRX and $4,788 for Direct Meds. HealthRX is lower by $2,640 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Evidence status
Both figures carry the same evidence status, reported: sourced from dated third-party reporting; first-party capture pending. Neither is stronger than the other on provenance.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
HealthRX Official site
HealthRX offers flat per-dose compounded GLP-1 pricing on 12-month and 3-month commitment plans. Its $99/mo semaglutide and $179/mo tirzepatide on the twelve-month plan rank among the lowest annualized figures in the market. No month-to-month rate is published.
It does not publicly name its compounding pharmacy; the record shows healthrx.com (pharmacy partner not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are 12-month or 3-month plans only; no month-to-month rate published; cancellation is Per provider terms; confirm at enrollment; availability is stated as Confirm availability at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, capture verified 2026-07-18 on healthrx.com
Watch: HealthRX publishes no month-to-month rate; the $99/mo sema and $179/mo tirz are 12-month plan rates. The lowest commitment available is the 3-month plan ($133 sema, $209 tirz). Reported status — RangeYourself verified 2026-07-18 on healthrx.com; our independent checkout is pending.
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
What neither record tells you
HealthRX does not publish
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm availability at intake
- no specific cancellation or refund terms
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask HealthRX and Direct Meds for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. HealthRX, Direct Meds carry a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Prepaid terms move the annual figures. HealthRX publishes a twelve-month rate of $179 a month against $209 month-to-month. Read those next to the cancellation terms, not the monthly rate.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, HealthRX Official site wins this matchup. If you expect to titrate to the top of the ladder, healthrx's flat pricing is worth more than the headline gap suggests.
Both figures should be checked at the provider's own checkout before you pay. HealthRX's tirzepatide price is reported as of 2026-07-18; Direct Meds's is reported as of 2026-07-25.
Questions
Is HealthRX or Direct Meds cheaper for tirzepatide?
HealthRX is cheaper on all-in monthly cost at 10 mg/week: $209 against $399, a difference of $190 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of HealthRX versus Direct Meds?
HealthRX works out to $2,148 across twelve months and Direct Meds to $4,788, on the plan terms each publishes.
Does HealthRX or Direct Meds raise the price as the dose goes up?
HealthRX: no, it charges one flat rate at every dose. Direct Meds: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do HealthRX and Direct Meds differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of HealthRX and Direct Meds names its pharmacy?
Neither. HealthRX records healthrx.com (pharmacy partner not publicly named) and Direct Meds records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the HealthRX and Direct Meds prices?
HealthRX's tirzepatide figure is reported — sourced from dated third-party reporting; first-party capture pending — captured 2026-07-18. Direct Meds's is reported, captured 2026-07-25. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
HealthRX, at $133 a month all-in against $297 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: HealthRX official site · Direct Meds official site. Compounded tirzepatide and semaglutide are not FDA-approved products.